Discussion of: Brownian distance covariance

We discuss briefly the very interesting concept of Brownian distance covariance developed by Sz\'{e}kely and Rizzo [Ann. Appl. Statist. (2009), to appear] and describe two possible extensions. The first extension is for high dimensional data that can be coerced into a Hilbert space, including certain high throughput screening and functional data settings. The second extension involves very simple modifications that may yield increased power in some settings. We commend Sz\'{e}kely and Rizzo for their very interesting work and recognize that this general idea has potential to have a large impact on the way in which statisticians evaluate dependency in data. [arXiv:1010.0297]Comment: Published in at http://dx.doi.org/10.1214/09-AOAS312B the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org). With Correction

Q-learning with censored data

We develop methodology for a multistage decision problem with flexible number of stages in which the rewards are survival times that are subject to censoring. We present a novel Q-learning algorithm that is adjusted for censored data and allows a flexible number of stages. We provide finite sample bounds on the generalization error of the policy learned by the algorithm, and show that when the optimal Q-function belongs to the approximation space, the expected survival time for policies obtained by the algorithm converges to that of the optimal policy. We simulate a multistage clinical trial with flexible number of stages and apply the proposed censored-Q-learning algorithm to find individualized treatment regimens. The methodology presented in this paper has implications in the design of personalized medicine trials in cancer and in other life-threatening diseases.Comment: Published in at http://dx.doi.org/10.1214/12-AOS968 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

Higher order semiparametric frequentist inference with the profile sampler

We consider higher order frequentist inference for the parametric component of a semiparametric model based on sampling from the posterior profile distribution. The first order validity of this procedure established by Lee, Kosorok and Fine in [J. American Statist. Assoc. 100 (2005) 960--969] is extended to second-order validity in the setting where the infinite-dimensional nuisance parameter achieves the parametric rate. Specifically, we obtain higher order estimates of the maximum profile likelihood estimator and of the efficient Fisher information. Moreover, we prove that an exact frequentist confidence interval for the parametric component at level $\alpha$ can be estimated by the $\alpha$-level credible set from the profile sampler with an error of order $O_P(n^{-1})$. Simulation studies are used to assess second-order asymptotic validity of the profile sampler. As far as we are aware, these are the first higher order accuracy results for semiparametric frequentist inference.Comment: Published in at http://dx.doi.org/10.1214/07-AOS523 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

Penalized log-likelihood estimation for partly linear transformation models with current status data

We consider partly linear transformation models applied to current status data. The unknown quantities are the transformation function, a linear regression parameter and a nonparametric regression effect. It is shown that the penalized MLE for the regression parameter is asymptotically normal and efficient and converges at the parametric rate, although the penalized MLE for the transformation function and nonparametric regression effect are only $n^{1/3}$ consistent. Inference for the regression parameter based on a block jackknife is investigated. We also study computational issues and demonstrate the proposed methodology with a simulation study. The transformation models and partly linear regression terms, coupled with new estimation and inference techniques, provide flexible alternatives to the Cox model for current status data analysis.Comment: Published at http://dx.doi.org/10.1214/009053605000000444 in the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org